TCO PEG linker (or Thiol-Containing Oligo PEG Linker) is a type of linker molecule used in bioconjugation, biocatalysis and other biological and chemical applications. The TCO PEG linker is composed of two main components: a thiol-containing oligomer (TCO) and a polyethylene glycol (PEG) segment. The purpose of the linker is to provide a stable, biocompatible connection between two molecules.
The thiol-containing oligomer (TCO) is an oligomeric molecule that consists of a thiol (sulfur-containing) group, typically attached to carbon atoms. The TCO is typically an eight-carbon chain, making it a relatively small molecule. The thiol group of the TCO can react with other molecules or groups, such as amines, alcohols, aldehydes, or thiols. This makes the TCO an ideal linker molecule for bioconjugation, as it can form covalent bonds with a variety of molecules.
The polyethylene glycol segment of the TCO PEG Linker is a polyether compound composed of repeating ethylene glycol units. PEG is a large, hydrophilic molecule that is commonly used in bioconjugation and other biological applications. The PEG segment is typically attached to the TCO via a hydrolysable ester bond. This ester bond is cleavable by hydrolysis, allowing for the release of the TCO from the PEG segment. This makes the TCO PEG linker an ideal molecule for bioconjugation and other applications, as it can be used to attach two molecules together, while also allowing for the release of the TCO upon hydrolysis.
The TCO PEG linker is a versatile molecule that can be used in a variety of applications. In bioconjugation, the TCO PEG linker can be used to attach two molecules together, such as proteins or peptides. In biocatalysis, the TCO PEG linker can be used to attach an enzyme to a substrate, allowing for the efficient catalysis of a reaction. The TCO PEG linker can also be used in drug delivery applications, where the TCO can be used to attach a drug to a polymer or other delivery vehicle. In addition, the TCO PEG linker can be used in the synthesis of polymeric materials, where the TCO can be used to attach a polymer to a surface or other substrate.
The TCO PEG linker is a useful and versatile linker molecule that has many applications in bioconjugation, biocatalysis, and drug delivery. The TCO PEG linker is composed of a thiol-containing oligomer and a polyethylene glycol segment, making it an ideal molecule for connecting two molecules together while also allowing for the release of the TCO upon hydrolysis. The versatility and stability of the TCO PEG linker make it an ideal molecule for a variety of biological and chemical applications.
AxisPharm has large production capacity for high quality TCO PEG reagents with amine, aminooxy, NHS ester and acid functionality. We also provide custom synthesis of PEG linkers modified folate, biotin and fluorescent dye for biological applications.
Buy TCO PEG: https://axispharm.com/product-category/peg-linkers/tco-peg/
