What is DSPE-PEG?



PEG phospholipids are excellent materials for forming liposomes, and can be used for gene transfection, vaccine delivery, drug delivery, and targeted drug delivery. Phospholipids are hydrophobic and hydrophilic. It can be used to modify protein drugs, peptide compounds, organic small molecule drugs, biological materials, etc. With the continuous accumulation and development of technology, PEGylated nanoliposomes have developed into a new type of drug delivery system with broad application prospects.

DSPE PEG linkers are PEG reagents containing lipid molecules such as DSPE and can be used in bioconjugation, drug formulation and nanoparticle delivery.

DSPE-PEG is a PEGylated phospholipid with good biocompatibility and biodegradability. It is often used as a nano-preparation carrier material to assist drug release and improve the biocompatibility and stability of the preparation. DSPE-PEG is an amphiphilic macromolecular compound, which is composed of a phosphate hydrophobic head and a PEG hydrophilic tail. It has good water solubility and can form a liposome structure together with phospholipids.

DSPE-PEG-NHS is one of the most commonly used reactive phospholipids and can be easily incorporated into liposomes and other nanoparticles; antibodies, peptides or other ligands can be conjugated to liposomes and other lipid PEG nanoparticles the surface of the particle.

The protein modified by DSPE-PEG-NHS or DSPE-PEG-NH2 as a carrier of SWNTs can quickly enter the cell in large quantities; DSPE-PEG-NHS is used to synthesize and modify the N-terminal of TxID to improve the peptide marine drug clue α-conotoxin TxID Stability and enzymatic resistance. The liposomes encapsulated by DSPE-PEG-NHS have better stability.