TCO-PEG6-acid contains a TCO moiety and a terminal carboxylic acid. The terminal carboxylic acid readily reacts with primary and secondary amine under EDC, DCC, HATU or other amide coupling conditions to form a stable amide bond. This reagent can react with tetrazine-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The PEG spacer increases the aqueous solubility of the resulting compound.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
Section I. Identification of the substance
Product Name: TCO-PEG6-acid
Catalog number: AP-10813
Supplier: AxisPharm, 9823 Pacific Heights Blvd, Suite F, San Diego, CA 92121
Tel: 1-858-677-9432, Email: sales@axispharm.com
Section II. Hazards identification
GHS—Classification
Classification – Not classified as a hazard
Section III. Composition and information on ingredients.
Name: TCO-PEG6-acid
Formula: C22H39NO9
MW 505.61:
CAS: N/A
Section IV. First aid measures
1. Skin contact: Immediately wash skin with copious amounts of water for at least 15
minutes while removing contaminated clothing and shoes. If irritation
persists, seek medical attention.
2. Eye contact: Immediately wash skin with copious amounts of water for at least 15
minutes. Assure adequate flushing of the eyes by separating the eyelids
with fingers. If irritation persists, seek medical attention.
3. Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek
medical attention.
4. Ingestion: Washoutmouthwithcopiousamountsofwaterforatleast15minutes.Seek
medical attention.
Section V. Firefighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing
apparatus should be worn.
Section VI. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily
and meets local/state/national standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and
keep in a tightly closed container for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section VII. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those
properly qualified in the handling and use of potentially hazardous chemicals, who
should take into account the fire, health and chemical hazard data given on this
sheet.
Storage: Store in closed vessels, refrigerated.
Section VIII. Exposure Controls / PPE
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear chemical-resistant gloves, safety goggles.
General hygiene measures: Wash thoroughly after handling. Wash contaminated clothing
before reuse.
Section IX. Physical and chemical properties
Appearance: liquid
Odor: No data
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C22H39NO9
Molecular weight: 505.61
Section X. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: No data available.
Section XI. Toxicological information
No data
Section XII. Ecological information
No data
Section XIII. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local
waste disposal authority, in accordance with national and regional regulations.
Section XIV. Transportation information
Non-hazardous for air and ground transportation.
Section XV. Regulatory information
Indication of Danger: No data.
Risk Statement: No data.
Safety Statement: In case of contact with eyes, rinse immediately with plenty of water and seek
medical advice. Wear suitable gloves and eye/face protection.
Section XVI. Other information
This SDS is correct to the best of our knowledge and belief at the date of its publication but
does not purport to be all inclusive and shall be used only as a guide. AxisPharm shall not
be held liable for any loss, injury or damage which may result from its use. This product is
for research and development use only.
