TCO PEG acid NHS esters are versatile adc linkers. They readily react with biomolecules with amine functional groups. The resulting TCO tagged biomolecules can further undergo fast bioorthogonal reaction with tetrazine activated molecules to form stable ADCs.

Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.

Section I. Identification of the subs tance

Product Name: TCO PEG3 CH2CONHS
Catalog number: AP-10040
Supplier: AxisPharm, 9823 Pacific Heights Blvd, Suite F, San Diego, CA 92121
Tel: 1 -858-677-9432, Email:

Section II. Hazards identification

GHS — Cla ssification
Classification – No t cl ass ified a s a haz ard

Section III. Composition and informat ion on ingredients.

Fo rmu la : C21H32N2O 9
MW: 456.49

Section IV. First aid measures

1. Skin contact: Immediately wash skin with copiou s amounts of water for at lea st 15
minutes while removing contaminated clothing and shoes. If irritation
persists, seek medical attention.
2. Eye contact: Immediately wa sh skin with copiou s amounts of water for at lea st 15
minutes. Assure adequate flu shing of the eyes by separating the eyelids with
fingers. If irritation persists, seek medical attention.
3. Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical
4. Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek
medical attention.

Section V. Firefighting measures

In the event of a fire involving this material, alone or in combination with other materia ls,
use dry powder or carbon dioxide extinguishers. Protective clothing and self -conta ined
breathing apparatu s should be worn.

Section VI. Accidental release measures

Personal precautions: Wear suitable personal protective equipment which performs satisfactorily
and meets local/state/na tional standards.
Respiratory precaution: Wear approved ma sk/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitab le protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent mater ial, sweep up and
keep in a tightly closed container for disposal. See section 12.
Environmental precautions: Do not allow ma ter ial to enter drains or water courses.

Section VII. Handling and s torage

Handling: This product should be handled only by, or under the close supervision of, those
properly qualified in the handling and use of potentially hazardou s chemicals, who
should take into account the fire, health and chemical hazard data given on this

Section VIII. Exposure Controls / PPE

Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear chemical -resistant gloves, sa fety goggles.
General hygiene measures: Wash thoroughly a fter handling. Wa sh contaminated clothing
before reu se.

Section IX . Phys ical and chemical properties

Appearance: liquid
Odor: No data
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C21H 32N2O9
Molecular weight: 456.49

Section X. Stability and reactivity

Conditions to avoid: Heat, flames and spark s.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: No data available.

Section XI. Toxicological information

No data

Section XII. Ecological information

No data

Section XIII. Disposal cons iderat ion

Arrange disposal a s special wa ste, by licensed disposal company, i n consultation with local
wa ste disposal authority, in accordance with na tional and regional regulations.

Section XIV. Transportation informat ion

Non-hazardou s for air and ground transportation.

Section XV. Regulatory information

Indication of Danger: No data.
Risk Statement: No data.
Safety Statement: In ca se of contact with eyes, rinse immediately with plenty of water and seek
medical advice. Wear suitable gloves and eye/face protection.

Section XVI. Other information

This MSDS is correct to the best of our knowledge and belief a t the date of its publication
but does not purport to be all inclu sive and shall be used only as a guide. AxisPharm shall
not be held liable for any loss, injury or damage which may result from its use. This
product is for research and development u se only.