TCO-NHS contains a TCO moiety and a NHS ester. The hydrophilic PEG spacer can increase water-solubility and a decreases steric hindrance during ligation. This NHS ester site can be used to label antibodies, proteins and other primary amine-containing macromolecules and the TCO end can be used to conjugate with tetrazine tagged biomolecules.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
Section I. Identification of the substance
Product Name: TCO-NHS
Catalog number: AP-10003
Supplier: AxisPharm, 9823 Pacific Heights Blvd, Suite F, San Diego, CA 92121
Tel: 1-858-677-9432, Email: sales@axispharm.com
Section II. Hazards identification
GHS — Classification
Classification – Not classified as a hazard
Section III. Composition and information on ingredients.
Name: TCO-NHS
Formula: C13H17NO5
MW: 267.3
CAS: 1191901-33-3
Section IV. First aid measures
1. Skin contact: Immediately wash skin with copious amounts of water for at least 15
minutes while removing contaminated clothing and shoes. If irritation
persists, seek medical attention.
2. Eye contact: Immediately wash skin with copious amounts of water for at least 15
minutes. Assure adequate flushing of the eyes by separating the eyelids with
fingers. If irritation persists, seek medical attention.
3. Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical
attention.
4. Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek
medical attention.
Section V. Firefighting measures
In the event of a fire involving this material, alone or in combination with other materials,
use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained
breathing apparatus should be worn.
Section VI. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily
and meets local/state/national standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and
keep in a tightly closed container for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section VII. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those
properly qualified in the handling and use of potentially hazardous chemicals, who
should take into account the fire, health and chemical hazard data given on this
sheet.
Section VIII. Exposure Controls / PPE
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear chemical-resistant gloves, safety goggles.
General hygiene measures: Wash thoroughly after handling. Wash contaminated clothing
before reuse.
Section IX. Physical and chemical properties
Appearance: liquid
Odor: No data
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C13H17NO5
Molecular weight: 267.3
Section X. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: No data available.
Section XI. Toxicological information
No data
Section XII. Ecological information
No data
Section XIII. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local
waste disposal authority, in accordance with national and regional regulations.
Section XIV. Transportation information
Non-hazardous for air and ground transportation.
Section XV. Regulatory information
Indication of Danger: No data.
Risk Statement: No data.
Safety Statement: In case of contact with eyes, rinse immediately with plenty of water and seek
medical advice. Wear suitable gloves and eye/face protection.
Section XVI. Other information
This MSDS is correct to the best of our knowledge and belief at the date of its publication
but does not purport to be all inclusive and shall be used only as a guide. AxisPharm shall
not be held liable for any loss, injury or damage which may result from its use. This
product is for research and development use only.
