propargyl-PEG4-acid is a PEG linker with a propargyl and a terminal carboxylic acid group on the ends. While the terminal carboxylic acid can react with primary and secondary amine groups in the presence amide coupling reagents (e.g. EDC, or DCC) to form a stable amide bond, the propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The increasing aqueous solubility derived from PEG spacer makes such linker an ideal conjugation linkers for biological applications.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
Section I. Identification of the subs tance
Product Name: propargyl-PEG3-CH2CH2COOH
Catalog number: AP-10292
Supplier: AxisPharm, 9823 Pacific Heights Blvd, Suite F, San Diego, CA 92121
Tel: 1 -858-677-9432, Email: firstname.lastname@example.org
Section II. Hazards identification
Classification – No t cl ass ified a s a haz ard
Section III. Composition and informat ion on ingredients.
Name: propargyl-PEG3 -CH2CH2COOH
Fo rmu la : C12H20O6
Section IV. First aid measures
1. Skin contact: Immediately wa sh skin with copiou s amounts of wa ter for at lea st 15
minutes while removing contaminated clothing and shoes. If
irritation persists, seek medical attention.
2. Eye contact: Immedia tely wash skin with copiou s amounts of water for at least 15
minutes. Assure adequate flu shing of the eyes by separating the eyelids
with fingers. If irritation persists, seek medical attention.
3. Inhalation: Remove to fresh air. In severe ca ses or if symptoms persist, seek
4. Ingestion: Washoutmouthwithcopiou samountsofwaterforatleast15minutes.Seek
Section V. Firefighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self -contained breathing
apparatu s should be worn.
Section VI. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily
and meets local/state/national standards.
Respiratory precaution: Wear approved ma sk/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent mater ial, sweep up and
keep in a tightly closed container for disposal. See section 12.
Environmental precautions: Do not allow ma ter ial to enter drains or water courses.
Section VII. Handling and s torage
Handling: This product should be handled only by, or under the close supervision of, those
properly qualified in the handling and use of potentially hazardou s chemicals, who
should take into account the fire, health and chemical hazard data given on this
Section VIII. Exposure Controls / PPE
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear chemical -resistant gloves, sa fety goggles.
General hygiene measures: Wash thoroughly a fter handling. Wa sh contaminated clothing
before reu se.
Section IX. Phys ical and chemical properties
Odor: No data
Boilingpoint: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C12H20O6
Molecular weight: 260.29
Section X. Stability and reactivity
Conditions to avoid: Heat, flames and spark s.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: No data available.
Section XI. Toxicological information
Section XII. Ecological information
Section XIII. Disposal cons iderat ion
Arrange disposal a s special wa ste, by licensed disposal company, i n consultation with local
wa ste disposal authority, in accordance with na tional and regional regulations.
Section XIV. Transportation informat ion
Non-hazardou s for air and ground transpor tation.
Section XV. Regulatory information
Indication of Danger: No data.
Risk Statement: No data.
Safety Statement: In case of contact with eyes, rinse immedia tely with plenty of water and seek
medical advice. Wear suitable gloves and eye/face protection.
Section XVI. Other information
This SDS is correct to the best of our knowledge and belief at the date of it s publication but
does not purport to be all inclu sive and shall be used only as a guide. AxisPharm shall not
be held liable for any loss, injury or damage which may result from its use. This product is
for research and development u se only.