DBCO-Maleimide is a sulfhydryl (thiol) reactive linker. It contains a maleimide and a DBCO group. The maleimide group reacts specifically and efficiently with thiols and forms a thioether bond. It has been widely used for cysteine-containing peptides/proteins or other thiol-containing biomolecules conjugations. DBCO readily undergoes copper free click chemistry with azide bearing biomolecules and form a stable triazole hinge.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
Section I. Identification of the substance
Product Name: DBCO-Mal
Catalog number: AP-10300
Supplier: AxisPharm, 9823 Pacific Heights Blvd , Suite F , Sa n Diego , CA 92121
Tel: 1-858-677 -9432 , Email: sales@axispha rm.com
Section II. Hazards identi fication
GHS—Classification
Classification – Not cl assifi e d as a ha za r d
Section III. Composition and in forma tion on ingred ients.
Name: DBCO-Mal
Formu la: C25H21N3O4
MW: 427.45
CAS: 1395786 -30-7
Section IV. First aid measures
1. Skin contact: Immediately was h skin with copious amounts of wate r fo r at least 15
minutes while removing contaminated clothing a nd shoes. If
irritat ion persists, seek medical attent ion.
2. Eye contact : Immediately was h skin with copious amounts of water for at least 15
minutes. Assure adequate flushing of the eyes by separating the eyelids
with f ingers. If irri tation persists, seek medical attention.
3. Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek
medical atte ntion.
4. Ingestion: Washou tmouthwithcopiousamountsofwaterforatleast15minutes.Seek
medical atte ntion.
Section V. Firefigh ting measures
In the eve nt of a fire involving this material , alone or in combination with other mate rials, use dry
powde r or carbon dioxide extinguis hers. Protective clothing a nd self-containe d breathing
apparatus should be wo rn.
Section VI. Accidental release measures
Persona l precautions : Wear suitable personal protective equipme nt whic h performs satisfactorily
and meets local/state/nat ional standa rds.
Respirato ry precaution: Wear approved mask/respirato r
Ha nd precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar ine rt absorbe nt material , sweep up and
keep in a tight ly closed container fo r disposal. See section 12.
Environmental precaut ions: Do no t allow mate rial to ente r drains or water courses.
Section VII. Handling and storage
Handling: T his product shou ld be ha ndled only by, or unde r the close supervision of, those
properly quali fied in the ha ndling a nd use of potentially haza rdous chemicals, who
should take into account the fi re, health a nd chemical ha zard data give n on this
sheet.
Section VIII. Exposure Contro ls / PPE
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear chemical-resista nt gloves, safety goggles.
General hygiene measures: Wash tho roughly after ha ndling. Was h contaminated clothing
before reuse.
Section IX. Physical and chemical properties
Appearance : liquid
Odor: No data
Boilingpoint: No data
Melting point : No data
Flash point: No data
Density: No data
Mole cular formula: C25H21N3O4
Mole cular weight: 427.45
Section X. Stabil ity and reactiv ity
Conditions to avoid: Heat , flames and sparks.
Materials to avoid: Oxidizing age nts.
Possible hazardous combustion products: No data available.
Section XI. Toxicological informa tion
No data
Section XII. Ecological information
No data
Section XIII. Disposal consideration
Arra nge disposal as special waste, by licensed disposal compa ny, i n consultation with local
waste disposal authori ty, in accorda nce wi th nat ional and re gional re gulations.
Section XIV. Transporta tion in forma tion
Non-haza rdous for air a nd ground tra nsportat ion.
Section XV. Regulatory informat ion
Indication of Danger: No data.
Risk Statement: No data.
Safety Statement: In case of contact with eyes, rinse immediately with ple nty of wate r and seek
medical advice. Wear suitable gloves and eye/face protection.
Section XVI. Other in forma tion
This SDS is correct to the best of our knowledge and belief at the date of its publication but
does not purpor t to be all inclusive and sha ll be used only as a guide. AxisPha rm shal l no t
be held liable for a ny loss, injury or dama ge whic h may result from its use. This product is
for research a nd developme nt use only.
